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Antioxidant, Anti-aging, Anti-inflammatory, Diseases of the heart and blood vessels, Liver disease, Cancer, Increases testosterone, Positive Effects on Estrogen Levels
Trans Resveratrol is one form of a compound produced by some plants to combat fungal infection. When ingested, trans Resveratrol might provide health benefits, ranging from protection against disease to antiaging properties.
The polyphenoic compound resveratrol belongs to the group of chemical compounds called stilbenes. Resveratrol comes in two forms, cis and trans, both of which may be attached to a glucose molecule. When attached to glucose, resveratrol is called a glucoside. Both the cis and trans forms can be found in nature, but they may not have the same biological properties when ingested. Most research on the potentially beneficial effects of resveratrol have been performed on the trans isomer.
Trans Resveratrol acts as a powerful antioxidant, binds to estrogen receptors, inhibits tumor activity and affects cellular enzymes. Most research done on trans-resveratrol uses doses much higher than the amounts found in natural sources. Animal studies have linked trans-resveratrol to heart protective effects, anticancer activity and antiaging properties.
Trans Resveratrol metabolism occurs rapidly once it is ingested, which means that it doesn't spend much time in the body before being altered and eliminated. The levels of trans-resveratrol and its metabolites are at their highest about 30 minutes after consumption, according to the Linus Pauling Institute.
Trans Resveratrol crosses the blood-brain barrier, offering support for the brain and nervous system. This allows for positive, direct support for neural health. A recent placebo-controlled study of 23 older adults observed significant improvements in memory among participants taking resveratrol, with the additional benefit of improved glucose metabolism.
Since the 1990s, the potential health benefits of Trans Resveratrol have been the subject of hundreds of studies. In particular, they have shown that resveratrol:
- interferes with a number of mechanisms involved in the development of cardiovascular disease:
- due to its antioxidant potency, it protects lipids from peroxidative damage and, in a dose-dependent manner, prevents oxidated LDL from entering the vascular wall (a key stage in the development of atherosclerosis),
- it appears to reduce secretion of VLDL by the liver, thus preventing hepatic metabolism of lipoproteins,
- it stops proliferation of cells in the blood vessels which restrict the lumen;
- it prevents many stages of carcinogenesis. It appears to fight cancer in a number of ways, from blocking oestrogens to modulating genes. It combats a many cancers both in terms of prevention and treatment. It destroys cancer cells and boosts certain chemotherapies;
- its anti-inflammatory action is as effective as that of the drug prednisone, with the additional benefit of providing free radical protection. It inhibits the release of inflammatory cytokines in obstructive pulmonary disease, making it an effective treatment for this lung disorder;
- it protects the brain from free radical attack and from beta-amyloid neurotoxicity;
- Its effects mimic those of caloric restriction, the only proven way to increase maximum lifespan. Resveratrol stimulates the creation of adiponectin, the same hormone observed to increase in individuals practicing caloric restriction. This hormone promotes metabolic and cardiovascular health through weight loss, lipid metabolism, and the regulation of blood sugar levels. Although the long-term effects of caloric restriction in humans continues to be evaluated, it has shown to advance longevity by 40% or more in some species;
- May Promote Healthy Testosterone Levels In Men. Research indicates resveratrol positively affects fertility and reproductive function in men. One study using animal models reported increased blood testosterone levels in supplemented groups. While this is good news for men of reproductive age, older men could possibly benefit as well. Testosterone strengthens bones, increases muscle mass, and encourages a positive outlook in men;
- Positive Effects on Estrogen Levels: Women who consume resveratrol appear to enjoy their own benefits. A study of 34 postmenopausal women taking 1 gram of resveratrol daily for 12 weeks reported improvements in estrogen metabolism and an increase of SHBG (steroid hormone binding globulin). SHBG enables the body to make better use of the availability of sex hormones already present. In essence, this study suggests resveratrol may support hormone balance.