Rejuvenation Research

EPITALON

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly), which is used to control pineal secretion processes. Epitalon exhibits several bioactivities including:

• improving eye retina condition in retinitis pigmentosa;

• anti-aging by activating chromatin in old age;

• showing anticancer and antitumour metastatic effects;

• and inhibiting osmotic stress-induced pathologic changes.

Epitalon controls cell function by inducing the production of telomerase, which repairs the telomeres, thereby rejuvenating the cells and allowing them to produce other cells. Long telomeres also assist in correcting DNA errors during cell division and prohibiting the degeneration of cells.

Telomeres are responsible for governing the lifespan of cells. With each cell division, telomeres shorten progressively until the cell can no longer divide and dies. When the telomeres becomes too short, its protective role is over. The cells understand this as a corruption of their DNA, enter senescence (the process of deterioration with age) and stop their growth. This sees the deterioration of organs as their constituent cells die or enter senescence.

Epitalon is scientifically proven as the strongest neurological factor in stopping the ageing of the human body and rejuvenating it.

In summary, Epitalon seems to be an anti-aging peptide with the potential to improve all levels of cellular health and aid in the repair of DNA.

The Benefits of Epitalon:

• Activates telomerase

• Elongates telomeres

• Promotes the survival of cells, resistance to stress and oxidative changes

• Balances the secretion of endocrine, improves pineal gland function and increases the release of  melatonin

• Attenuates excess secretions of cortisol from higher levels

• Increases antioxidant enzymes

• Increases brain health, stops brain cell aging and remodelling

• Restores quality of life and extends lifespan by performing the above-mentioned functions

• Epitalon is the only product that has been scientifically proven in medical studies and laboratory research on humans and cells

THYMALIN

Studies have shown that this immunomodulator molecule does occur naturally in the thymus. Thymus is a specialized bilobed secondary lymphoid organ which is critical to the development of functionally active and self-tolerant T-cells which is also a component of the adaptive immune system.Studies have shown that the actions of the thymus are mediated by immunomodulators.

The mature T-cells mediates the functions of the adaptive immune system. Loss (or sometimes complete absence) of the thymus before these population thresholds are reached results in DiGeorge Syndrome which is characterized by severe immunodeficiency. There is still residual T-cell lymphopoiesis throughout the adult life.

Nonetheless, studies have shown that complete involution of the thymus in old age is associated with increased susceptibility to severe infections and cancer development. This has been attributed to immune deficiency which impairs the immune response to infections and impairment of immune surveillance against tumors.

Other diseases associated with thymic dysfunction are allergic hypersensitivity, Severe Combined Immunodeficiency Syndrome (SCID), lymphomas, Myasthenia Gravis, thymomas and the rarity APECAD (Autoimmune PolyEndocrinopathy-Candidiasis-Ectodermal Dystrophy). Thymic immunomodulators have the potential of restoring the integrity of thymic activity in a dysfunctional or diseased thymus, thus treating the associated immune deficiency or managing its severity.

This version we carry is a tyhmic factor also known as thymulin, this peptide is endogenous to the human body. Pepetide sequence is Pyr-L-Ala-L-Lys-L-Ser-L-Gln-Gly-Gly-L-Ser-L-Asn-OH.

Researchers of the St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences and the Institute of Gerontology of the Ukrainian Academy of Medical Sciences (Kiev) clinically assessed the geroprotective effects of thymic (Thymalin) and pineal Epithalamin (Epitalon) peptide bioregulators in 266 elderly and older persons during 6-8 years both peptides were given at 10 mg daily for ten consecutive days once every 6 months. The bioregulators were applied for the first 2-3 years of observation.

The obtained results convincingly showed the ability of the bioregulators to normalize the basic functions of the human organism, i.e. to improve the indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism. Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control. Such a significant improvement in the health state of the peptide-treated patients correlated with decreased mortality rate during observation: 2.0-2.1-fold in the Thymalin-treated group; 1.6-1.8-fold in the Epithalamin-treated group; 2.5-fold in the patients treated with Thymalin plus Epithalamin (Epitalon) as compared to the control.

A separate group of patients was treated with Thymalin in combination with Epithalamin annually for 6 years and their mortality rate decreased 4.1 times as compared to the control.