INFLAMMATORY BOWEL DISEASE ADVANCED FORMULA - 30ml

BPC 157, Larazotide, and KPV are all peptides with important functions in the gastrointestinal tract. Their properties overlap, but are different enough that using them together may provide synergistic benefits in the setting on intestinal inflammation

BPC-157 ARGINATE SALT

BPC-157 arginate salt is very stable in human gastric juice and boosts the oral bioavailability from less than 3% to greater than 90%. BPC 157 arginate salt is also more stable in varied temperature environments and can resist the effects of UV light. Studies show that just 5% of BPC 157 arginate is degraded after 5 hours in gastric acid as compared to 98% of the acetate salt with oral administration. The enhanced oral bioavailability of the arginate salt makes it the preferred choice in BPC 157 oral research.

Wound and Gut Healing

Endogenous BPC production in the stomach maintains the integrity of the entire GI tract, protecting the mucosal barrier from acids and exogenous substances and foods that are known to damage tissues. BPC-157 not only maintains the integrity of the gut, but also promotes systemic healing of wounds, not limited to burns, gastric ulcers, and lacerations by promoting angiogenesis, overall cell growth and repair.

Cell Growth and Angiogenesis

Research has shown that BPC-157 increases blood vessel growth in all areas of the body. A study of chicken embryos demonstrated that BPC-157 increases vascular growth through the activation of cell surface receptors in the Nitrous Oxide pathway, growing new vessels toward the injury. This implies potential treatment of heart disease, overall cellular repair for life extension, and other general healing.

Drug Side Effects, Ulcers and Heart Attacks

BPC-157 has been shown to heal gastrointestinal, liver and brain lesions as a result of side effects produced by the use of NSAIDS, or non-steroidal anti-inflammatory drugs such as Celecoxib, Ibuprofen, Advil, etc. NSAIDS are known to cause ulcers, internal bleeding, heart attacks and various other dangerous conditions.

Anti-Inflammatory and Antioxidant

A study demonstrated that BPC-157 is a powerful antioxidant by reducing free radical formation via the Nitric Oxide system, attenuating duodenal lesions in rats by significantly decreasing oxidative stress.

Brain-Gut Axis Benefits and Antidepressant

BPC-157 was shown to modulate serotonin and dopamine with central influence benefits. A comparison with antidepressants found that BPC-157 was effective in attenuating depression.

LARAZOTIDE

Larazotide is a Zonulin receptor antagonist, a tight junction modulator. Larazotide inhibition of zonulin results in reducing trafficking across epithelial cells in the intestines and reducing intestinal permeability and "leaky gut," thought to be a gateway to multiple autoimmune diseases, including celiac disease, irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD, Crohn′s and ulcerative colitis), type 1 diabetes mellitus (T1DM), nonalcoholic steatohepatitis (NASH), chronic kidney disease (CKD), Hashimoto's thyroiditis and several others. It has been shown to inhibit the effect of inflammatory cytokines such as tumor necrosis factor (TNF-alpha) and interleukin (IL-4), blocking their increase of intestinal epithelial permeability.

KPV

KPV is a peptide that is naturally produced in the body. It is found in the hormone alpha-MSH. It is used for inflammation, gut health and conditions such as Inflammatory Bowel Disease

Anti-Inflammatory

KPV exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways. KPV enters the cell and interacts directly with inflammatory signalling molecules inside the cell. It enters the nucleus of the cell and, once there, can inhibit the interaction of inflammatory substances and molecules.

Anti-Microbial

In addition to its anti‐inflammatory effect, KPV also has antimicrobial effects against pathogens. Its antimicrobial effects were demonstrated on two major pathogens called staphylococcus aureus and Candida albicans. In one study, KPV significantly inhibited staphylococcus aureus from forming colonies.

Wound Healing

Research in wound healing shows KPV can speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. Often with wounds, various microbes enter the wound. KPV, with its anti-inflammatory and anti-microbial properties, can be very helpful for combatting these microbes and healing wounds.

Gut Issues: Ulcerative Colitis & Inflammatory Bowel Diseases (IBDs)

KPV significantly decreased inflammation in colitis. It decreases the inflammatory response by inhibiting proinflammatory cytokine (molecule) synthesis and secretion. KPV can stop the proinflammatory mechanisms in both intestinal epithelial cells and immune cells. It can interact directly with immune cells which can reduce inflammation. KPV may help in the case of IBDs through inhibited immune responses. Taken orally, KPV reduces the incidence of colitis, as shown by a decrease in proinflammatory cytokines. In the case of colitis, KPV reduced weight loss, colonic activity and decreased inflammation and proinflammatory cytokine levels.

Cancer

KPV treatment is able to decrease tumorigenesis. KPV was sufficient to decrease the inflammation of carcinogenesis. Using KPV before the development of colon cancer might be a preventive way to stop colonic carcinogenesis before it begins. The precise mechanism by which KPV decreases tumorigenesis is not yet fully understood.

.

REFERENCES:

https://www.gastrojournal.org/article/S0016-5085(07)01852-5/fulltext

https://jpet.aspetjournals.org/content/306/2/631

https://pubmed.ncbi.nlm.nih.gov/28143741/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403564/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095288/

https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13887

https://pubmed.ncbi.nlm.nih.gov/18061177/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957955/

https://www.sigmaaldrich.com/IT/en/tech-docs/paper/1020921