A Highly Potent, Orally Bioavailable, Non-steroidal.
Anabolic, Myotrophic, Neuroprotection/Neuroregeneration research, Alzheimer's Research
RAD140 is a highly potent selective androgen receptor modulator (SARM) that is non-steroidal, and orally bioavailable. It displays potent anabolic and neuroprotective effects. Its anabolic efficiency is similarly potent to testosterone. Its neuroprotective properties are essential in the therapeutic prevention and prevention of Alzheimer's disease and all other related neurodegenerative diseases.
Neuroprotective effects: SARM RAD140 shows effective neuroprotection. This is a significant neural action of endogenous androgens that is crucial for neural health and resilience to diseases that are neurodegenerative. It also portrays effectiveness as testosterone in slowing down cell death caused by apoptotic insults. Notably, androgens have shown to increase the cell survival of adult-born neurons in the dentate gyrus through a mechanism that is androgen receptor-dependent in male rats. Mechanically, the neuroprotection effectiveness of RAD140 relied upon MAPK signalling. This was evidenced by the increase of ERK phosphorylation and protection inhibition by the MEK inhibitor U0126. More specifically, RAD140 was also neuroprotective in vivo using the rat kainate (excitotoxin) lesion model.
Anabolic effects: RAD140 exhibited peripheral particular tissue androgen action that significantly spared prostate and neural efficiency, as shown by the stimulation of androgenic gene regulation effects, showing profound selection for anabolic actions and also neuroprotection. As compared with testosterone (120%), RAD140 portrays superior anabolic effect but has lower androgenic effects (ventral prostate and seminal vesicle enlargement side effects). Simultaneous use of testosterone and RAD140 demonstrated strengthened (modestly superior) anabolic effects of testosterone. RAD140 additionally reduced the androgenic side effects of testosterone on the prostate. Thus, it has proved that the administration of RAD140 along with the testosterone can achieve greater therapeutic efficiency and indices.