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Improvements in memory function, learning ability and verbal fluency, Parkinson’s disease.
The product known as PRL-8-53 is a research nootropic compound. It gets its name from the research facility where it was created; Pacific Research Labs. PRL-8-53 was initially synthesized by Dr N. Hansl when he was at Creighton University. Pacific Research Labs, where the compound was created, held the first patent which subsequently expired. Only a single study on humans has been undertaken. The results on participants in the study shows an 80% increase in verbal memory as well as remarkable increase in short-term memory which lasted significantly.
Most patients who use PRL-8-53 provide anecdotal evidence that any memory improvement is vividly clear and lasts for a long time. This property makes PRL-8-53 an excellent nootropic for anyone studying, such as high school and college students. It can also be used by anyone who wishes to improve their memory. There are also less official reports indicating that this research compound can provide relief to patients suffering from amnesia with a single dose.
The mechanism of action of PRL-8-53 is not known but scientists believe it is a factor of cholinergic mechanisms. The creator of the compound, Dr Hansl, explains in a scientific journal, the Phi Delta Kappan, that the compound enhances the action of the brain as a response to acetylcholine but is not a stimulant. There were tests conducted using PRL-8-53 in rodents. The tests indicated that 4mg per Kg of PRL-8-53 resulted in higher compulsive gnawing in rats. This means that PRL-8-53 could be a dopamine agonist. The test also indicated conditioned avoidance learning. It is evident that PRL-8-53 does not inhibit MAO activity and does not promote amphetamine’s actions.