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Unifiram is a drug in the racetam family. Its structure is like ampakine, and it is closely related to Sunifiram. Unifiram is one of the most potent brain supplements. Evidence has shown that it is a thousand times stronger than aniracetam. Clinical experiments over the years have shown that unifiram can boost memory and improve cognitive abilities like other nootropics that are racetam. Studies have shown that unifiram is a positive allosteric AMPA receptor modulator.
It acts to reduce effects of antagonists of NMDA, muscarinic and AMPA. AMPA and NMDA antagonist copy the functioning of glutamate, and for that reason, they are directly associated with memory and learning in the brain. It is also able to control glutamate uptake in the brain hence improving the neuronal synaptic transmission. Like piracetam, oxiracetam, pramiracetam and noopept, it stimulates acetylcholine production.
Several experiments on animals such as rats have shown that as unifiram increases acetylcholine, it also reduces amnesic effects of scopolamine. Test subjects reduced amnesia in the mice and increased their ability to memorise the right path in a maze test.
The fact that it reduces muscarinic antagonist explains why it increases the level of acetylcholine. The M1 muscarinic receptor is a cholinergic receptor. In research, it has been observed that unifiram has the following main advantages; anti-sedative and anti-hypnotic effects, anti-amnesia and acetylcholine agonism. In one study, it was found that unifiram could reduce effects of barbiturates which are hypnosis and sedation. Since acetylcholine is strongly correlated to improved memory and learning, unifiram can, therefore, be useful in brain development.
The safety of unifiram is like the rest of the nootropic agents, although more research needs to be done on this drug to uncover its effects.