Major depressive disorder, Post traumatic stress disorder, Neurogenesis in the hippocampal formation, Increase levels of neurons in the brain, Nootropic and Neuroprotective proprietes
NSI-189 is a neurological and nootropic research and experimental benzylpiperazine-aminopyridine developed by Neuralstem, Inc. NSI-189 is an agent derived from pyrazine and nicotinamide. Studies from randomised and controlled trials have indicated that NSI-189 stimulates neuronal cell production (neurogenesis). In animal controlled trials it has been found that NSI-189 increases hippocampal volume by close to 20% hence not only curbing but also reversing behavioural symptoms of depression.
The hippocampus area of the brain is in charge of spatial control and consolidation of short-term memory to long-term memory. In other words, NSI-189 phosphate aims to improve mood by stimulating the growth of new neurons in the hippocampus.
NSI-189’s mechanism of action remains a trade secret, but it has been speculated that it works by binding to the glucocorticoid receptor. Binding the glucocorticoid receptor can result in a decrease in the circulation of cortisol. Cortisol is an adrenal hormone, specifically a stress hormone, often associated with regulating body changes in response to stress. It is also often associated with a majority of stress-related neuropsychiatric conditions and depression.
The idea behind NSI-189 phosphate is that it can alleviate depression, treat post-traumatic stress disorder, take care of age-related cognitive conditions, and treat Alzheimer’s disease, as well as counter and reverse symptoms seen in disorders such as MDD.
The reason why NSI-189 phosphate has the potential to become a game changer in the medicinal world is that trials have revealed that NSI-189 phosphate addresses three significant factors, including neurogenesis, neurotransmission, and hippocampal volume. Therefore, it has the potential to help promote healthy cell density thus enhancing cognitive performance, facilitate healthy growth of new neuron cells, improve the functionality of neuron cells, and repair damaged areas of the brain.