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NSI-189 Phosphate Powder - 2g, 5g

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Major depressive disorder, Post traumatic stress disorder, Neurogenesis in the hippocampal formation, Increase levels of neurons in the brain, Nootropic and Neuroprotective proprietes

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NSI-189 Phosphate Powder - 2g, 5g

Major depressive disorder, Post traumatic stress disorder, Neurogenesis in the hippocampal formation, Increase levels of neurons in the brain, Nootropic and Neuroprotective proprietes

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NSI-189 is a neurological and nootropic research and experimental benzylpiperazine-aminopyridine developed by Neuralstem, Inc. NSI-189 is an agent derived from pyrazine and nicotinamide. Studies from randomised and controlled trials have indicated that NSI-189 stimulates neuronal cell production (neurogenesis). In animal controlled trials it has been found that NSI-189 increases hippocampal volume by close to 20% hence not only curbing but also reversing behavioural symptoms of depression.

The hippocampus area of the brain is in charge of spatial control and consolidation of short-term memory to long-term memory. In other words, NSI-189 phosphate aims to improve mood by stimulating the growth of new neurons in the hippocampus.

NSI-189’s mechanism of action remains a trade secret, but it has been speculated that it works by binding to the glucocorticoid receptor. Binding the glucocorticoid receptor can result in a decrease in the circulation of cortisol. Cortisol is an adrenal hormone, specifically a stress hormone, often associated with regulating body changes in response to stress. It is also often associated with a majority of stress-related neuropsychiatric conditions and depression.

The idea behind NSI-189 phosphate is that it can alleviate depression, treat post-traumatic stress disorder, take care of age-related cognitive conditions, and treat Alzheimer’s disease, as well as counter and reverse symptoms seen in disorders such as MDD.

The reason why NSI-189 phosphate has the potential to become a game changer in the medicinal world is that trials have revealed that NSI-189 phosphate addresses three significant factors, including neurogenesis, neurotransmission, and hippocampal volume. Therefore, it has the potential to help promote healthy cell density thus enhancing cognitive performance, facilitate healthy growth of new neuron cells, improve the functionality of neuron cells, and repair damaged areas of the brain.
Label Information

Ingredients: NSI-189 (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone

Formula: C22H30N4O

CAS: 1270138-40-3

Purity: Greater than 99.0%

Ship code/Instructions: Ambient temperature only.

Storage Instructions: NSI-189 should not be refrigerated. Store at room temperature only

Dosage: Due to the fact that NSI-189 phosphate is still a trial drug, there has not yet been a fixed dosage. However, during the trials patients were given daily doses of 40mg, 80mg, and 120mg at the highest dose per day over the course of 28 days. During this period, patients did not report any serious events or side effects, and the NSI-189 phosphate was found to be well tolerated. Also, there was a significant reduction in depression and cognitive symptoms for patients taking the lower doses of 40mg and 80mg, but not for those taking 120mg per day. The preliminary findings of the trials are supportive of the idea that NSI-189 phosphate can treat MDD. Nonetheless, further studies on the dosage and the method of action of NSI-189 phosphate are imperative to help confirm preliminary observations and help draw conclusions.

Side effects: The majority of the side effects of NSI-189 phosphate seem to be dose-related. Reported side effects include mild sedation, fatigue, increased appetite, and difficulty waking up in the morning. Due to its promising benefits, it can be tempting for individuals to think that the higher the dosage, the better the results. On the brighter side, NSI-189 phosphate shows great promise and could in the near future replace SSRI’s and other drugs ridden with side-effects that are currently being used to treat mood disorders and improve memory. So far, NSI-189 phosphate appears to be devoid of the adverse side effects that plaque medications used to treat mood disorder have.

ATTENTION: This compound should be used for research purposes only. All chemical compounds have risks. Please consult your physician and understand the available research before consumption. This product is not intended to diagnose, treat, cure, or prevent any disease.